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Professional Summary
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Daniel P. Healy, PharmD, FCCP, FIDSA, Professor, Division of Pharmacy Practice and Administrative Sciences, Winkle College of Pharmacy: has an established research program involved the preclinical/clinical pharmacology and experimental therapeutics of antimicrobials and biologic response modifiers used in the treatment of serious infections in burned hosts.
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Research Support
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Grant #HEA-SHR1 Healy, Daniel 01/01/2012 12/31/2012 Shriners Hospitals for Children - Cincinnati Shriners-College of Pharmacy Healy Consultant Agreement for FY12 Role:PI $23,859.00 Closed Private Non-Profit
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Grant #Prime W81XWH-11-2-0233-P00001 Babcock, George; Healy, Daniel 09/30/2011 03/30/2013 Department of the Army Medical Research Acquisition Activity The use of TheraGauze in the Treatment of Burn Wounds Role:Collaborator $163,595.00 Closed Federal
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Grant #70011 Healy Healy, Daniel 01/01/2011 12/31/2011 Shriners Hospitals for Children - Cincinnati Shriners-College of Pharmacy 2011 Consulting Agreement Role:PI $22,608.00 Closed Private Non-Profit
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Grant #Shriner's Agreement - Healy Healy, Daniel 01/01/2008 12/31/2009 Shriners Hospitals for Children - Cincinnati Shrine College of Pharmacy 2008 Consulting Agreement for Dr. Daniel Healy Role:PI $39,934.00 Closed Private Non-Profit
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Publications
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Peer Reviewed Publications
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Chung, E. K., Cheatham, S. C., Healy, D. P., Stock, A. H., Utley, S., Campion, M., Murrey, T., Gesenhues, A. M., Jeffery, J., & Kays, M. B. (2023). Population pharmacokinetics and pharmacodynamics of cefazolin using total and unbound serum concentrations in patients with high body weight. International Journal of Antimicrobial Agents, 61(4), 106751.DOI:10.1016/j.ijantimicag.2023.106751
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Sherwin, C. M., Tran, N. K., Sullivan, K., Wead, S., Birnbaum, A. K., Avachat, C., Healy, D. P., & Kagan, R. J. (2023). Exploring the Past to Inform the Future to Optimize the Pharmacokinetics of Vancomycin in Children With Severe Burn Injuries. Journal of Burn Care & Research : Official Publication of the American Burn Association, 44(2), 353-362.DOI:10.1093/jbcr/irac147
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Al-Shaer, M. H., Maguigan, K., Ashton, J., Venugopalan, V., Droege, M. E., Philpott, C. D., Droege, C. A., Healy, D. P., Mueller, E. W., & Peloquin, C. A. (2022). Applying Cefepime Population Pharmacokinetics to Critically Ill Patients Receiving Continuous Renal Replacement Therapy. Antimicrobial Agents and Chemotherapy, 66(1), e0161121.DOI:10.1128/AAC.01611-21
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Al-Shaer, M. H., Philpott, C. D., Droege, C. A., Courter, J. D., Healy, D. P., Droege, M. E., Ernst, N. E., Mueller, E. W., & Peloquin, C. A. (2021). Cefepime population pharmacokinetics and target attainment in critically ill patients on continuous renal replacement therapy. Antimicrobial Agents and Chemotherapy. DOI:10.1128/AAC.00144-21
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Philpott, C. D., Droege, C. A., Droege, M. E., Healy, D. P., Courter, J. D., Ernst, N. E., Harger, N. J., Foertsch, M. J., Winter, J. B., Carter, K. E., Van Fleet, S. L., Athota, K., & Mueller, E. W. (2019). Pharmacokinetics and Pharmacodynamics of Extended-Infusion Cefepime in Critically Ill Patients Receiving Continuous Renal Replacement Therapy: A Prospective, Open-Label Study. Pharmacotherapy, 39(11), 1066-1076.DOI:10.1002/phar.2332
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Liu, X., Smits, A., Wang, Y., Renard, M., Wead, S., Kagan, R. J., Healy, D. P., De Cock, P., Allegaert, K., & Sherwin, C. M. T. (2019). Impact of Disease on Amikacin Pharmacokinetics and Dosing in Children. Therapeutic Drug Monitoring, 41(1), 44-52.DOI:10.1097/FTD.0000000000000568
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Rice, T. C., Armocida, S. M., Kuethe, J. W., Midura, E. F., Jain, A., Hildeman, D. A., Healy, D. P., Gulbins, E., & Caldwell, C. C. (2017). Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner. Cellular Immunology, 313, 25-31.DOI:10.1016/j.cellimm.2016.12.004
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Chung, E. K., Cheatham, S. C., Fleming, M. R., Healy, D. P., & Kays, M. B. (2017). Population Pharmacokinetics and Pharmacodynamics of Meropenem in Nonobese, Obese, and Morbidly Obese Patients. Journal of Clinical Pharmacology, 57(3), 356-368.DOI:10.1002/jcph.812
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Kuethe, J. W., Armocida, S. M., Midura, E. F., Rice, T. C., Hildeman, D. A., Healy, D. P., & Caldwell, C. C. (2016). Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury. Shock (Augusta, Ga.), 45(6), 647-52.DOI:10.1097/SHK.0000000000000551
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Nichols, K., Chung, E. K., Knoderer, C. A., Buenger, L. E., Healy, D. P., Dees, J., Crumby, A. S., & Kays, M. B. (2016). Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children. Antimicrobial Agents and Chemotherapy, 60(1), 522-31.DOI:10.1128/AAC.02089-15
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Kuethe, J. W., Armocida, S. M., Midura, E. F., Rice, T. C., Hildeman, D. A., Healy, D. P., & Caldwell, C. C. (2016). Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury. Shock (Augusta, Ga.), 45(6), 647-52.DOI:10.1097/SHK.0000000000000551
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Nichols, K., Chung, E. K., Knoderer, C. A., Buenger, L. E., Healy, D. P., Dees, J., Crumby, A. S., & Kays, M. B. (2016). Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children. Antimicrobial Agents and Chemotherapy, 60(1), 522-31.DOI:10.1128/AAC.02089-15
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Chung, E. K., Cheatham, S. C., Fleming, M. R., Healy, D. P., Shea, K. M., & Kays, M. B. (2015). Population pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese and nonobese patients. Journal of Clinical Pharmacology, 55(8), 899-908.DOI:10.1002/jcph.505
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Yu, T., Stockmann, C., Healy, D. P., Olson, J., Wead, S., Neely, A. N., Kagan, R. J., Spigarelli, M. G., & Sherwin, C. M. T. (2015). Determination of Optimal Amikacin Dosing Regimens for Pediatric Patients With Burn Wound Sepsis. Journal of Burn Care & Research : Official Publication of the American Burn Association, 36(4), e244-52.DOI:10.1097/BCR.0000000000000159
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Stockmann, C., Spigarelli, M. G., Healy, D. P., Gottschlich, M. M., Kagan, R., Balch, A. H., & Sherwin, C. (2015). Application of a method used to deconstruct a single dose pharmacokinetic profile from multiple dose data. Biopharmaceutics & Drug Disposition. DOI:10.1002/bdd.1949
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DiMuzio, E. E., Healy, D. P., Durkee, P., Neely, A. N., & Kagan, R. J. (2015). Trends in bacterial wound isolates and antimicrobial susceptibility in a pediatric burn hospital. Journal of Burn Care & Research : Official Publication of the American Burn Association, 35(5), e304-11.DOI:10.1097/BCR.0000000000000058
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Stockmann C, Buterbaugh W, Healy DP, Spigarelli MG, Neely AN, Kagan RJ Sherwin CMT. (2015). Relationship between Zolpidem Concentrations and Sleep Parameters in Pediatric Burn Patients. J Burn Care Res, 36, 137.
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Stockmann C, Sherwin CMT, Buterbaugh W, Spigarelli M, Gottschlich MM, Healy DP, Kagan RJ. (2014). Population pharmacokinetics of zolpidem as a sleep-enhancing agent among paediatric burn patients. Ther Drug Monit, 36, 295.
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Cheatham, S. C., Fleming, M. R., Healy, D. P., Chung, E. K., Shea, K. M., Humphrey, M. L., & Kays, M. B. (2014). Steady-state pharmacokinetics and pharmacodynamics of meropenem in morbidly obese patients hospitalized in an intensive care unit. Journal of Clinical Pharmacology, 54(3), 324-30.DOI:10.1002/jcph.196
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Cheatham, S. C., Fleming, M. R., Healy, D. P., Chung, E. K., Shea, K. M., Humphrey, M. L., & Kays, M. B. (2014). Steady-state pharmacokinetics and pharmacodynamics of meropenem in morbidly obese patients hospitalized in an intensive care unit. Journal of Clinical Pharmacology, 54(3), 324-30.DOI:10.1002/jcph.196
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Stockmann, C., Sherwin, C. M. T., Buterbaugh, W., Spigarelli, M. G., Gottschlich, M. M., Healy, D., & Kagan, R. J. (2014). Preliminary assessment of zolpidem pharmacokinetics in pediatric burn patients. Therapeutic Drug Monitoring, 36(3), 295-301.DOI:10.1097/FTD.0000000000000017
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Sherwin, C. M. T., Wead, S., Stockmann, C., Healy, D., Spigarelli, M. G., Neely, A., & Kagan, R. (2014). Amikacin population pharmacokinetics among paediatric burn patients. Burns : Journal of the International Society For Burn Injuries, 40(2), 311-8.DOI:10.1016/j.burns.2013.06.015
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Cheatham, S. C., Fleming, M. R., Healy, D. P., Chung, C. E. K., Shea, K. M., Humphrey, M. L., & Kays, M. B. (2013). Steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese patients. International Journal of Antimicrobial Agents, 41(1), 52-6.DOI:10.1016/j.ijantimicag.2012.09.004
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Knoderer, C. A., Saft, S. A., Walker, S. G., Rodefeld, M. D., Turrentine, M. W., Brown, J. W., Healy, D. P., & Sowinski, K. M. (2011). Cefuroxime pharmacokinetics in pediatric cardiovascular surgery patients undergoing cardiopulmonary bypass. Journal of Cardiothoracic and Vascular Anesthesia, 25(3), 425-30.DOI:10.1053/j.jvca.2010.07.022
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Cheatham, S. C., Shea, K. M., Healy, D. P., Humphrey, M. L., Fleming, M. R., Wack, M. F., Smith, D. W., Sowinski, K. M., & Kays, M. B. (2011). Steady-state pharmacokinetics and pharmacodynamics of cefepime administered by prolonged infusion in hospitalised patients. International Journal of Antimicrobial Agents, 37(1), 46-50.DOI:10.1016/j.ijantimicag.2010.08.016
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Healy, D. P., Sombun, A. D., Gardner, J. C., Good, K., Durkee, P. J., Toner, L., Rieman, M. T., Neely, A. N., & Kagan, R. J. (2011). Pharmacokinetics of colistin in an adolescent boy with extensive burn injury. Journal of Burn Care & Research : Official Publication of the American Burn Association, 32(1), e7-11.DOI:10.1097/BCR.0b013e318203352a
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Utrup, T. R., Mueller, E. W., Healy, D. P., Callcut, R. A., Peterson, J. D., & Hurford, W. E. (2010). High-dose ciprofloxacin for serious gram-negative infection in an obese, critically ill patient receiving continuous venovenous hemodiafiltration. The Annals of Pharmacotherapy, 44(10), 1660-4.DOI:10.1345/aph.1P234
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Peterson JW, Moen ST, Healy D, Pawlik JE, Taormina J, Hardcastle J, Thomas JM, Lawrence WS, Ponce C, Parham T, Chatuev BM,Gnade BT, Foltz SM, Agar SL, Sha J, Klimpel GR, Kirtley ML, Eaves-Pyle T, Chopra AK (2010). Protection afforded by fluoroquinolones in animal models of respiratory infections with Bacillus anthracis, Yersinia pestis, and Francisella tularensis. The Open Microbiol J, 4, 34.
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Stockmann, C., Gottschlich, M. M., Healy, D., Khoury, J. C., Mayes, T., Sherwin, C. M. T., Spigarelli, M. G., & Kagan, R. J. Relationship between zolpidem concentrations and sleep parameters in pediatric burn patients. Journal of Burn Care & Research : Official Publication of the American Burn Association, 36(1), 137-44.DOI:10.1097/BCR.0000000000000164
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Positions and Work Experience
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1985 -1987 Clinical Instructor Virginia Commonwealth University/ Medical College of Virginia Department of Pharmacy/ Pharmaceutics
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1987 -1990 Research Assistant Professor Virginia Commonwealth University/ Medical College of Virginia Department of Pharmacy/ Pharmaceutics
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1990 -1994 Assistant Professor, Division of Pharmacotherapy College of Pharmacy, University of Cincinnati
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1991 to Present Full member, Graduate Faculty University of Cincinnati
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1993 to Present Scientific Staff, Department of Research and Microbiology Shriners Hospitals for Children Cincinnati Unit
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1994 to Present Associate Professor Division of Pharmacy Practice, College of Pharmacy, University of Cincinnati
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2010 to Present Professor Division of Pharmacy Practice College of Pharmacy, University of Cincinnati
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Education
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Institution:Albany College of Pharmacy Albany, NY Bachelor of Science in Pharmacy 1982
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Institution:Veterans Administration Medical Center Tampa, Florida ASHP Residency in Hospital Pharmacy 1983
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Institution:University of Kentucky Doctor of Pharmacy 1984
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Institution:College of Pharmacy University of Kentucky Medical Center Clinical Research Scientist 1985
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Institution:Virginia Commonwealth University/ Medical College of Virginia Richmond, Virginia ASHP Research Fellowship, Infectious Diseases Pharmacotherapy 1987
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Institution:Department of Pharmacy and Pharmaceutics School of Pharmacy Virginia Commonwealth University/Medical College of Virginia Research Coordinator Antibiotic Research Unit 1990
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Institution:Department of Immunology Shriners Burns Institute Academic Leave (sabbatical) 1998
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Research and Practice Interests
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Pre-clinical pharmacology and experimental therapeutics of antimicrobials and immunomodulators in bacterial sepsis; immunomodulatory properties of antimicrobials; PK/PD clinical studies
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Preferred Information
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Professor Daniel Healy Degrees:PharmD No
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Contact Information
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Address type:Research Location Name:Healy's Lab 3255 Eden Ave. 287 KOW Cincinnati 36 45229 273 Phone:8596090487 Email:daniel.healy@uc.edu County:KY
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